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Effects of Champex, as proven by In-Vitro and In-Vivo tests
Section Three - Purification of Blood
3-1 - Suppression of indoleacetic acid and triptamine levels in the blood
Purpose
The blood levels of indoleacetic acid and tryptamine in the rabbit, those are metabolites of tryptophan and subsequently absorbed from the intestine, were measured and the obtained assay values were used as criteria for the assessment of effects of Champex in this study.
Method
Twenty-one (21) healthy rabbits were divided into 3 groups. Group 1, which consisted of 5 rabbits, was served as a control group. The five (5) rabbits in Group 2 were orally administered via a catheter with a mixed solution of trytophan at 1.0 g/kg and 10 ml of water. The eleven (11) rabbits in Group 3 were orally administered via a catheter with a mixed solution of tryptophan at 1.0 g/kg, 10 ml of water, and further supplemented with Champex at 0.25 ml/kg. Each group was provided with water and feeds ad libitum. A one (1) ml blood sample was taken from the ear vein of the rabbits in each group at 1, 3, 6, 9 and 12 hours after administration,
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and the serum was separated by prompt centrifugation of the blood sample at 3000 rpm for 10 minutes to remove proteins. The supernatant was filtrated with a 0.45µm filter (DISMIC) and subjected to a HPLC measurement.
Result
The results are presented Figures in 3 and 4. Indolacetic acid and tryptamine were detected in the serum when tryptophan was orally administered to rabbits. In the rabbits that received simultaneous administration of tryptophan and Champex, however, no tryptamine was detected and the level of indoleacetic acid in the serum was at an undetectable level 12 hours after administration was begun. Thus, the oral administration of Champex accomplished the successful elimination of indolacetic acid and tryptamine in the blood, and is indicative of its future use in the cleanup of body wastes in the blood.
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3-2 - Control of ammonia blood level in elderly humans
Data presented at the 36th Congress of Tohoku Clinical & Hygienic Examination Society
The average ammonia blood levels of 14 aged inpatients following administration of Champex at 500mg for 30 days showed a 52% reduction from 93µg/dl before the administration to 45µg/dl at the completion of the Champex administration trials.
Data presented to the 13th Japan Stoma Rehabilitation Society, 1996
When "Shu-Clean", a Champex product, was administered at a level of 5 pieces per day for 30 days to 9 patients, each of whom had an artificial anus, the average blood ammonia
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levels showed a 40% reduction from 46µg/dl before the Champex administration trials to 28 93µg/dl at the completion of the trials.
Data published in the December '96 edition of STORE-AGE
MASHROM, a Champex finished product was administered at the rate of 2 sachets a day to a 61-year-old female hyperammonemia inpatient who had been suffering from cirrhosis. Her blood ammonia level was 182µg/dl prior to the start of administration and decreased to 82µg/dl at the completion of the administration trial.
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